After being all out for 433 with Tim Ambrose out on 99, Adam Shantry ripped apart Sussex with an eleven ball spell which bought four wickers for three runs.
More good bowling saw Sussex dismissed for 168 with Warwicks 77-2 at the close,having lost both Westwood and Maddy.
In the test match at The Oval,India were 316-4 after ninety overs.