Warwicks resumed on 270-7 and but lost wickets early with Tim Ambrose out for 86 to end their innings on 315.
Chris Woakes ripped Worcestershire apart taking 6-98 as Glamorgan were all out for 193 after being 45-5. Jamie Dairymple offered some resistance with 92.
Warwicks batted again and were 55-3 at the close,some 177 runs ahead.
Tomorrow's play starts at 10.30am.