After the washout yesterday, Warwicks tore into the home batsmen.
Mitchell was first to lose his wicket with the score on eight. Then Vicram Solanki (27) and Moore (28) offered some resistance before Chris Woakes and Neil Carter struck.
Woakes recorded figures of 4-30 and Carter 5-37 as Worcestershire were skittled out for 111.
The follow on was enforced and against Mitchell was out early. Moore made 88 and Solanki 46 as Worcestershire ended the day on 206-6, some eight runs ahead with four wickets remaining.
In the Third Ashes match at Edgbaston, Ian Bell made 53 including seven fours and a six as England replied to Australia's first innings with a score of 379 all out. Andrew Flintoff made 74, Andrew Strauss 69 and Stuart Broad 55.
At stumps, Australia were 88-2, 25 runs behind.