Ian Westwood added forty more runs to his over night total of 139 but he fell victim to Jamie Dairyimple, Frost was out for 45 and Ant Botha added 62 before he was run out.
Robert Croft took the remaining wickets and Warwicks were all out for 421.
In reply, Glamorgan were 183-5 at the close with three wickets for Jimmy Anyon.
Play is due to start at 11am in the morning and you can listen to the game on the net via the BBC Coventry & Warwickshire website.
In the test match at Trent Bridge, England's dominance with the ball saw New Zealand all out for 123 thanks to 7-43 from James Anderson.
Skipper Michael Vaughan ordered the tourists to follow on and although Brendan McCullum made fifty not out, New Zealand were 177-5 with Tim Ambrose taking two catches.