Greg Rioch is likely to be without Jordan Clarke and Curtis Wynter who are again expected to be on first team duty for the game which kicks off at the Alan Higgs Centre at 11am.
City have already played at MK Dons this season and drew 2-2 whilst City's Academy Director was in the crowd when MK Dons played at Coventry Sphinx Youth last month.
Last Saturday, the Dons lost 3-0 at Aston Villa with the Sky Blues without a fixture due to Reading's FA Youth Cup involvement.
The Sky Blues are third in the table with MK Dons bottom with only five points from fourteen matches. The referee is R.Patterson.