"It is a sickening blow for Isaac and a real disappointment to both him and us," said Coleman to the CT, "It is unbelievable really to lose both Stephen and Isaac.
"To lose one is bad enough, but at least you have still got cover, but to lose both is a real blow.
"Wrighty has hurt his medial knee ligaments after he went in for a block tackle.
"It felt sore and he couldn't go on in the game and it looks as if he will be out for anything between two to four weeks.
"I feel for Isaac as well because he has done well for us this season. I had a chat with him before the Sheffield Wednesday game when I left him out for two reasons.
"Firstly, we had Wrighty back and we were up against a particularly tricky winger so we wanted his experience in there, and, secondly, Isaac was on four bookings and we wanted to save him.
"But we talked about his desire to play in midfield and I have been looking to maybe give him his chance there.
"He's only a young lad but he's a strong character and he'll bounce back."